Alberta Health Services says that the first person in Alberta to die from influenza this season is from Calgary.
There is no information on the age of gender of the victim at this time.
According to the report from AHS, released on Thursday, there have been 80 people admitted to hospital for treatment of lab-confirmed influenza in the Calgary Zone.
The Calgary Zone is also the most prolific in number of flu cases (248) say the latest numbers.
Just over 344,000 doses of the influenza vaccine have been administered in the Calgary zone, with just over 305,000 doses given out in the Edmonton Zone.
Vaccines are offered free of charge to all Albertans aged six months and older.
Children under five years old, seniors, people living in care homes, pregnant women, First Nations people and those with chronic health conditions are at the highest risk of becoming seriously ill from influenza.
To find out about your local immunization clinic, you can go to the AHS website.
